The Charged Aerosol Detector (CAD) is increasingly valued in modern liquid chromatography analysis for its broad response to non-volatile compounds, good quantitative performance, and ease of operation. It shows significant advantages especially when dealing with targets that lack UV absorption, are difficult to ionize, or have no chromatographic response.
Glucose, as a representative polar carbohydrate without UV absorption, is a typical sample for evaluating CAD performance. Its stable structure and clear physicochemical properties make it suitable as a model compound for testing detector sensitivity, response consistency, linear range, and baseline stability.
This report systematically tests glucose samples using the Charged Aerosol Detector independently developed by Instrumax, comprehensively examining its performance in detecting polar small molecules. By comparing response conditions, repeatability indicators, and baseline performance at different concentrations, it aims to verify the detector's application potential in sugar analysis and provide technical support for future expansion into complex systems (such as traditional Chinese medicine, food, and metabolite analysis). Sorry, your browser doesn't support embedded videos. Click to view full text