. Mono-tert-butyl eicosanedioate (20-(tert-Butoxy)-20-oxoicosanoic acid) is a long-chain alkyldicarboxylic acid derivative with acidity. It can be synthesized by esterification and is mainly used as an intermediate in organic synthesis. This compound is important in pharmaceutical synthesis, especially in the preparation of bioactive molecules such as insulin derivatives for treating diseases including diabetes and obesity.
During the preparation of mono-tert-butyl eicosanedioate, the target compound and related substances have weak UV absorption. A charged aerosol detector (CAD) can therefore serve as an efficient detection method for monitoring reaction progress and identifying product purity. HPLC-CAD is used to detect intermediates and final products in the synthesis process, ensuring high selectivity and high yield of the synthetic route. The CAD detector plays a key role in ensuring synthesis efficiency and product quality control. Click to view full text