. In the 2020 edition of the Chinese Pharmacopoeia, related substances of ursodeoxycholic acid are tested by thin-layer chromatography, and assay is performed by titration. This article develops a charged aerosol detection method to improve the applicability and repeatability of the original method, increase the detection limit for impurities and improve the quality control level of this drug. The charged aerosol detector (CAD) is a new type of universal detector developed in recent years.
Its detection is independent of the molecular structure of the analyte, and the analyte does not need to be ionized. As long as the analyte is semi-volatile or non-volatile, CAD can be used for detection. At the same time, CAD is a mass-sensitive detector. The response value is determined by the absolute mass of the detected sample. When the absolute mass of the detected sample is the same, the measured response values are basically consistent, and lower detection limits and higher sensitivity can be obtained. Click to view full text.