The Charged Aerosol Detector (CAD) has become one of the important universal detectors in liquid chromatography detection due to its universal response capability to a wide range of non-volatile compounds, good quantitative performance, and ease of operation.
As a representative of domestic high-end detection instruments, the Charged Aerosol Detector independently developed by Instrumax aims to achieve breakthroughs in performance, stability, and domestic substitution capability. Caffeine is a representative alkaloid widely present in complex matrices such as food, beverages, and pharmaceuticals. It has moderate polarity and strong stability, suitable for both UV detection and as a test model for examining CAD response capability.
Using caffeine as the analysis object can cover CAD's response capability to moderately polar small molecules and examine its quantitative linearity, response consistency, and detection sensitivity across different concentration ranges. This report systematically tests and evaluates caffeine performance based on Instrumax CAD, covering key indicators such as method establishment, linear range, sensitivity, repeatability, and baseline stability. It aims to verify the instrument's applicability in general small molecule detection and provide data support for its application in drug analysis, food safety, quality control, and other fields. Click to view full text