. Because of its universal response to a wide range of nonvolatile compounds, good quantitative performance, and simple operation, the charged aerosol detector (CAD, Charged Aerosol Detector) has become an important universal detector in liquid chromatography. As a representative China-developed high-end detector, the charged aerosol detector independently developed by Instrumax is designed to achieve breakthroughs in performance, stability, and China-made substitution capability.
Caffeine is a representative alkaloid widely present in complex matrices such as foods, beverages, and pharmaceuticals. It has moderate polarity and strong stability, can be used for UV detection, and is also suitable as a test model for evaluating CAD response capability.
Using caffeine as the analyte covers CAD response to moderately polar small molecules and evaluates quantitative linearity, response consistency, and detection sensitivity across different concentration ranges. This report conducts systematic testing and performance evaluation of caffeine using Instrumax CAD, covering method establishment, linear range, sensitivity, repeatability, and baseline stability. It aims to verify the instrument’s applicability in universal small-molecule detection and provide data support for applications in pharmaceutical analysis, food safety, quality control, and related fields. Click to view full text